PMID- 15838107
OWN - NLM
STAT- MEDLINE
DA  - 20050419
DCOM- 20051109
PUBM- Print
IS  - 0077-8923 (Print)
VI  - 1038
DP  - 2004 Dec
TI  - Neuroendocrine basis of human disease.
PG  - 131-7
AB  - This paper is a short review of the traditionally obvious diseases of
      neuroendocrine origin (diabetes insipidus, Kallman syndrome, etc.), but
      also of the newly recognized participation of several peptides originally
      characterized in the hypothalamus and of their receptors, in a series of
      diseases, both in internal medicine and in psychiatry (rheumatoid
      arthritis, inflammation, carcinoids, anxiety, depression, etc.). The
      concept of neuropeptides is now vastly expanded, as these molecules and
      their several receptors are now known to be widely distributed throughout
      the brain and the periphery with increasing evidence of paracrine and
      autocrine modes of action.
AD  - The Salk Institute for Biological Studies, 10010 North Torrey Pines Road,
      La Jolla, CA 92037, USA. Guillemin@salk.edu
FAU - Guillemin, Roger
AU  - Guillemin R
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences.
JID - 7506858
SB  - IM
MH  - Endocrine System Diseases/history/*physiopathology
MH  - History, 20th Century
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Neuroendocrine Tumors/physiopathology
MH  - Neurosecretory Systems/*physiology
MH  - Pituitary Gland/metabolism
EDAT- 2005/04/20 09:00
MHDA- 2005/11/10 09:00
AID - 1038/1/131 [pii]
AID - 10.1196/annals.1315.021 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci 2004 Dec;1038:131-7.

PMID- 15642779
OWN - NLM
STAT- MEDLINE
DA  - 20050111
DCOM- 20050225
LR  - 20051117
PUBM- Print
IS  - 0022-0795 (Print)
VI  - 184
IP  - 1
DP  - 2005 Jan
TI  - Hypothalamic hormones a.k.a. hypothalamic releasing factors.
PG  - 11-28
AB  - Originally searched for and eventually isolated as factors of hypothalamic
      origin controlling anterior pituitary secretions, these hypophysiotropic
      peptides are now a chapter of physiology and medical endocrinology of
      their own. Defying the concept of 'neuropeptides' they and their receptors
      are now known to be ubiquitous and to have subtle as well as profound
      effects on a large number of functions of both soma and psyche. This
      review will be composed of brief essays on current knowledge of each of
      the original 'hypothalamic hormones', TRH, GnRH, somatostatin, GHRH and
      corticotropin releasing hormone and will close on possible and probable
      futures.
AD  - Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La
      Jolla, California 92037, USA.
FAU - Guillemin, Roger
AU  - Guillemin R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology.
JID - 0375363
RN  - 0 (Hypothalamic Hormones)
RN  - 24305-27-9 (Thyrotropin-Releasing Hormone)
RN  - 33515-09-2 (Gonadorelin)
RN  - 51110-01-1 (Somatostatin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - 9034-39-3 (Somatotropin-Releasing Hormone)
SB  - IM
MH  - Corticotropin-Releasing Hormone/physiology
MH  - Gonadorelin/physiology
MH  - Humans
MH  - Hypothalamic Hormones/*physiology
MH  - Hypothalamus/physiology
MH  - Pituitary Gland, Anterior/physiology
MH  - Somatostatin/physiology
MH  - Somatotropin-Releasing Hormone/physiology
MH  - Thyrotropin-Releasing Hormone/physiology
RF  - 114
EDAT- 2005/01/12 09:00
MHDA- 2005/02/26 09:00
AID - 184/1/11 [pii]
AID - 10.1677/joe.1.05883 [doi]
PST - ppublish
SO  - J Endocrinol 2005 Jan;184(1):11-28.

PMID- 12462241
OWN - KIE
STAT- MEDLINE
DA  - 20021202
DCOM- 20021204
LR  - 20041117
PUBM- Print
IS  - 0190-8286 (Print)
DP  - 2001 Feb 22
TI  - Nobel laureates' letter to President Bush.
PG  - A02
FAU - Arrow, K J
AU  - Arrow KJ
FAU - Axelrod, J
AU  - Axelrod J
FAU - Benacerraf, B
AU  - Benacerraf B
FAU - Berg, P
AU  - Berg P
FAU - Bishop, J M
AU  - Bishop JM
FAU - Bloembergen, N
AU  - Bloembergen N
FAU - Brown, H C
AU  - Brown HC
FAU - Cibelli, J
AU  - Cibelli J
FAU - Cohen, S
AU  - Cohen S
FAU - Cooper, L N
AU  - Cooper LN
FAU - Corey, E J
AU  - Corey EJ
FAU - Cronin, J W
AU  - Cronin JW
FAU - Curl, R Jr
AU  - Curl R Jr
FAU - Dulbecco, R
AU  - Dulbecco R
FAU - Fischer, E H
AU  - Fischer EH
FAU - Fitch, V L
AU  - Fitch VL
FAU - Fogel, R
AU  - Fogel R
FAU - Friedman, J I
AU  - Friedman JI
FAU - Furchgott, R F
AU  - Furchgott RF
FAU - Gell-Mann, M
AU  - Gell-Mann M
FAU - Gilbert, W
AU  - Gilbert W
FAU - Gilman, A
AU  - Gilman A
FAU - Glaser, D
AU  - Glaser D
FAU - Glashow, S L
AU  - Glashow SL
FAU - Green, R M
AU  - Green RM
FAU - Greengard, P
AU  - Greengard P
FAU - Guillemin, R
AU  - Guillemin R
FAU - Hayflick, L
AU  - Hayflick L
FAU - Hauptman, H A
AU  - Hauptman HA
FAU - Heckman, J J
AU  - Heckman JJ
FAU - Heeger, A
AU  - Heeger A
FAU - Herschbach, D
AU  - Herschbach D
FAU - Hubel, D H
AU  - Hubel DH
FAU - Hulse, R
AU  - Hulse R
FAU - Kandel, E
AU  - Kandel E
FAU - Karle, J
AU  - Karle J
FAU - Klein, L R
AU  - Klein LR
FAU - Kohn, W
AU  - Kohn W
FAU - Kornberg, A
AU  - Kornberg A
FAU - Krebs, E G
AU  - Krebs EG
FAU - Lanza, R P
AU  - Lanza RP
FAU - Laughlin, R
AU  - Laughlin R
FAU - Lederman, L
AU  - Lederman L
FAU - Lee, D M
AU  - Lee DM
FAU - Lewis, E
AU  - Lewis E
FAU - Lipscomb, W Jr
AU  - Lipscomb W Jr
FAU - Marcus, R A
AU  - Marcus RA
FAU - McFadden, D
AU  - McFadden D
FAU - Merrifield, R B
AU  - Merrifield RB
FAU - Merton, R
AU  - Merton R
FAU - Modigliani, F
AU  - Modigliani F
FAU - Molina, M J
AU  - Molina MJ
FAU - Murad, F
AU  - Murad F
FAU - Nirenberg, M W
AU  - Nirenberg MW
FAU - North, D C
AU  - North DC
FAU - Olah, G A
AU  - Olah GA
FAU - Osheroff, D
AU  - Osheroff D
FAU - Palade, G E
AU  - Palade GE
FAU - Perl, M
AU  - Perl M
FAU - Ramsey, N F
AU  - Ramsey NF
FAU - Richter, B
AU  - Richter B
FAU - Roberts, R J
AU  - Roberts RJ
FAU - Samuelson, P A
AU  - Samuelson PA
FAU - Schwartz, M
AU  - Schwartz M
FAU - Sharp, P A
AU  - Sharp PA
FAU - Smalley, R E
AU  - Smalley RE
FAU - Smith, H O
AU  - Smith HO
FAU - Solow, R M
AU  - Solow RM
FAU - Stormer, H
AU  - Stormer H
FAU - Taube, H
AU  - Taube H
FAU - Taylor, R
AU  - Taylor R
FAU - Thomas, E D
AU  - Thomas ED
FAU - Tobin, J
AU  - Tobin J
FAU - Tonegawa, S
AU  - Tonegawa S
FAU - Townes, C
AU  - Townes C
FAU - Watson, J D
AU  - Watson JD
FAU - Weinberg, S
AU  - Weinberg S
FAU - Weller, T H
AU  - Weller TH
FAU - West, M D
AU  - West MD
FAU - Wieschaus, E F
AU  - Wieschaus EF
FAU - Wiesel, T N
AU  - Wiesel TN
FAU - Wilson, R W
AU  - Wilson RW
LA  - eng
PT  - Newspaper Article
PL  - United States
TA  - Washington Post
JT  - Washington post (Washington, D.C. :  1974)
JID - 9877133
SB  - E
MH  - Embryo Disposition
MH  - *Embryo Research
MH  - Federal Government
MH  - Financing, Government
MH  - Humans
MH  - National Institutes of Health (U.S.)
MH  - *Research Support
MH  - *Stem Cells
MH  - United States
OID - KIE: 104583
OID - NRCBL: VF 18.5.4
OTO - KIE
OT  - Biomedical and Behavioral Research
OT  - Genetics and Reproduction
GN  - KIE: KIE Bib: embryo and fetal research
EDAT- 2002/12/05 04:00
MHDA- 2002/12/05 04:01
PST - ppublish
SO  - Washington Post 2001 Feb 22;:A02.

PMID- 12256596
OWN - PIP
STAT- MEDLINE
DA  - 19800103
DCOM- 19800103
LR  - 20021004
PUBM- Print
IS  - 0368-1610 (Print)
VI  - 34
DP  - 1972 Feb
TI  - Stimulation of ovulation in the rabbit triggered by synthetic LRF.
PG  - 434-6
FAU - Amoss, M
AU  - Amoss M
FAU - Blackwell, R
AU  - Blackwell R
FAU - Guillemin, R
AU  - Guillemin R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol
JT  - The Journal of clinical endocrinology.
JID - 17840150R
RN  - 0 (Hormones)
RN  - 0 (Pituitary Hormone-Releasing Hormones)
SB  - J
MH  - *Animals, Laboratory
MH  - Biology
MH  - Endocrine System
MH  - Hormones
MH  - *Ovulation
MH  - Physiology
MH  - *Pituitary Hormone-Releasing Hormones
MH  - Reproduction
MH  - Research
OID - PIP: 720722
OID - POP: 00021490
OAB - PIP: Results in previous experiments led to the assumption that if electr
      ical stimulation of the hypothalamus in the rabbit stimulates the release
      of LH-releasing factor (LRF), which in turn induces the secretion of LH
      and FSH leading to  ovulation in the constant estrous rabbit, then
      peripheral injection of LRF alone with no other hormonal treatment should
      trigger ovulation in the rabbit.  It was determined in a study of 30
      rabbits that a single iv injection of synthetic LRF with no other hormonal
      pretreatment regularly stimulated ovulation.  The minimal dose active in
      all animals appeared to be 1 mcg (200 ng/kg body weight).  No ovulation
      was ever observed in the control animals injected with saline.  At all
      doses (1, 10, and 50 mcg), it appeared that LRF was more active when
      administered as a single injection than over a 30-minut e iv infusion.  An
      increasing number of ova were released as the dose of injected LRF
      increased.
OTO - PIP
OT  - *Animals, Laboratory
OT  - Biology
OT  - Clinical Research
OT  - Endocrine System
OT  - Hormones
OT  - *Ovulation
OT  - Physiology
OT  - *Pituitary Hormone Releasing Hormones--administraction and dosage
OT  - *Pituitary Hormone Releasing Hormones--side effects
OT  - Reproduction
OT  - Research Methodology
EDAT- 2002/09/25 06:00
MHDA- 2002/10/09 04:00
PST - ppublish
SO  - J Clin Endocrinol 1972 Feb;34:434-6.

PMID- 7878461
OWN - NLM
STAT- MEDLINE
DA  - 19950406
DCOM- 19950406
LR  - 20041117
PUBM- Print
IS  - 0036-8075 (Print)
VI  - 267
IP  - 5203
DP  - 1995 Mar 10
TI  - Floyd Bloom: the next editor-in-chief of Science.
PG  - 1441-2
AD  - Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
FAU - Lerner, R A
AU  - Lerner RA
FAU - Guillemin, R
AU  - Guillemin R
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - UNITED STATES
TA  - Science
JT  - Science.
JID - 0404511
SB  - IM
SB  - Q
MH  - Administrative Personnel
MH  - History, 20th Century
MH  - Neuropharmacology/history
MH  - *Periodicals/history
MH  - Portraits
MH  - *Science/history
MH  - United States
PS  - Bloom F
FPS - Bloom, F
EDAT- 1995/03/10
MHDA- 1995/03/10 00:01
PST - ppublish
SO  - Science 1995 Mar 10;267(5203):1441-2.

PMID- 3086749
OWN - NLM
STAT- MEDLINE
DA  - 19860723
DCOM- 19860723
LR  - 20041117
PUBM- Print
IS  - 0028-0836 (Print)
VI  - 321
IP  - 6072
DP  - 1986 Jun 19-25
TI  - Pituitary FSH is released by a heterodimer of the beta-subunits from the
      two forms of inhibin.
PG  - 779-82
AB  - Inhibin is a gonadal protein that specifically inhibits the secretion of
      pituitary follicle-stimulating hormone (FSH). Two forms of inhibin (A and
      B) have been purified from porcine follicular fluid and characterized as
      heterodimers of relative molecular mass (Mr) 32,000 (ref. 2). Each inhibin
      is comprised of an identical alpha-subunit of Mr 18,000 and a distinct but
      related beta-subunit of Mr 13,800-14,700 linked by interchain disulphide
      bond(s). Throughout the purification of inhibins, we consistently observed
      two fractions which stimulated the secretion of pituitary FSH. We report
      here the isolation of one of the FSH-releasing proteins; it has a Mr of
      24,000 and its N-terminal sequences up to residue 32 are identical to
      those of each beta-subunit of inhibins A and B. In the presence of
      reducing agents, SDS-polyacrylamide gel electrophoresis resolves the
      FSH-releasing substance into two subunits which are identical in their
      migration behaviour to the reduced beta-subunits of inhibins A and B.
      Based on the N-terminal sequence data and Mr of the intact and reduced
      molecules, we propose that the FSH-releasing substance, which is active in
      picomolar concentrations, is a heterodimeric protein composed of the two
      beta-subunits of inhibins A and B linked by interchain disulphide bond(s).
      The structural organization of the FSH-releasing substance is homologous
      to that of transforming growth factor-beta (TGF-beta), which also
      possesses FSH-releasing activity in the same bioassay. We suggest that the
      substance be called activin to signify the fact that it has opposite
      biological effects to inhibin.
FAU - Ling, N
AU  - Ling N
FAU - Ying, S Y
AU  - Ying SY
FAU - Ueno, N
AU  - Ueno N
FAU - Shimasaki, S
AU  - Shimasaki S
FAU - Esch, F
AU  - Esch F
FAU - Hotta, M
AU  - Hotta M
FAU - Guillemin, R
AU  - Guillemin R
LA  - eng
GR  - AM-18811/AM/NIADDK
GR  - HD-09690/HD/NICHD
GR  - MH-00663/MH/NIMH
GR  - AG 03106/AG/NIA
GR  - AM-18811/AM/NIADDK
GR  - DK-26741/DK/NIDDK
PT  - Journal Article
PL  - ENGLAND
TA  - Nature
JT  - Nature.
JID - 0410462
RN  - 0 (Disulfides)
RN  - 0 (Macromolecular Substances)
RN  - 57285-09-3 (Inhibins)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Body Fluids/analysis
MH  - Comparative Study
MH  - Disulfides
MH  - Female
MH  - Follicle Stimulating Hormone/*secretion
MH  - Inhibins/*physiology
MH  - Macromolecular Substances
MH  - Molecular Weight
MH  - Ovarian Follicle/*analysis
MH  - Research Support, Non-U.S. Gov't
MH  - Research Support, U.S. Gov't, P.H.S.
MH  - Swine
EDAT- 1986/06/19
MHDA- 1986/06/19 00:01
PST - ppublish
SO  - Nature. 1986 Jun 19-25;321(6072):779-82.