PMID- 12679283 OWN - NLM STAT- MEDLINE DA - 20030407 DCOM- 20030827 LR - 20041117 PUBM- Print IS - 1537-4416 (Print) VI - 32 IP - 2 DP - 2003 Jun TI - Preventive intervention for urban, low-income preschoolers at familial risk for conduct problems: a randomized pilot study. PG - 246-57 AB - Conducted a pilot study to test the feasibility of a prevention program for promoting parenting in families of preschoolers at high risk for behavior problems. Risk status was based on a family history of antisocial behavior and residence in a low-income, urban community. Thirty preschoolers (ages 21/2 to 5) and their parents were randomly assigned to a 1-year, home- and clinic-based intervention or to a no-intervention control condition. Despite families' multiple risk factors, high rates of attendance and satisfaction were achieved. Relative to controls, intervention parents were observed to be significantly more responsive and use more positive parenting practices. Results support the feasibility of engaging high-risk families in an intensive prevention program. The meaningful changes achieved in parenting suggest that a preventive approach is promising for families with multiple risk factors. AD - New York University Child Study Center, New York, NY 10016, USA. laurie.miller.2@med.nyu.edu FAU - Brotman, Laurie Miller AU - Brotman LM FAU - Klein, Rachel G AU - Klein RG FAU - Kamboukos, Dimitra AU - Kamboukos D FAU - Brown, Elissa J AU - Brown EJ FAU - Coard, Stephanie Irby AU - Coard SI FAU - Sosinsky, Laura Stout AU - Sosinsky LS LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Clin Child Adolesc Psychol JT - Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. JID - 101133858 SB - IM MH - Adult MH - Antisocial Personality Disorder/etiology/*prevention & control/psychology MH - Attention Deficit and Disruptive Behavior Disorders/etiology/*prevention & control/psychology MH - Child Behavior Disorders/etiology/*prevention & control/psychology MH - Child of Impaired Parents/*psychology MH - Child, Preschool MH - Combined Modality Therapy MH - Data Interpretation, Statistical MH - *Early Intervention (Education) MH - Feasibility Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - New York City MH - Outcome and Process Assessment (Health Care)/statistics & numerical data MH - *Parenting MH - Pilot Projects MH - *Poverty/psychology MH - Research Support, Non-U.S. Gov't MH - Risk Assessment/statistics & numerical data MH - Socialization MH - *Urban Population EDAT- 2003/04/08 05:00 MHDA- 2003/08/28 05:00 PST - ppublish SO - J Clin Child Adolesc Psychol. 2003 Jun;32(2):246-57. PMID- 8931843 OWN - NLM STAT- MEDLINE DA - 19970218 DCOM- 19970218 LR - 20051116 PUBM- Print IS - 0895-7061 (Print) VI - 9 IP - 11 DP - 1996 Nov TI - Introduction to the symposium: the sympathetic nervous system really is a key element in hypertension, with treatment implications. PG - 111S-112S AD - Department of Medicine, University of Minnesota, Minneapolis 55455, USA. FAU - Tobian, L AU - Tobian L FAU - Bunn, P AU - Bunn PA JR LA - eng PT - Journal Article PL - UNITED STATES TA - Am J Hypertens JT - American journal of hypertension : journal of the American Society of Hypertension. JID - 8803676 SB - IM MH - Animals MH - Humans MH - Hypertension/*etiology/therapy MH - Sympathetic Nervous System/*physiology RF - 4 EDAT- 1996/11/01 MHDA- 1996/11/01 00:01 AID - 0895706196004256 [pii] PST - ppublish SO - Am J Hypertens 1996 Nov;9(11):111S-112S. PMID- 2417121 OWN - NLM STAT- MEDLINE DA - 19860213 DCOM- 19860213 LR - 20041117 PUBM- Print IS - 0028-0836 (Print) VI - 318 IP - 6047 DP - 1985 Dec 19-1986 Jan 1 TI - Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. PG - 659-63 AB - Inhibin, a specific and potent polypeptide inhibitor of the secretion of follicle-stimulating hormone (FSH), of gonadal origin and thus a potential contraceptive, may constitute a missing link in the mechanism controlling the differential secretion of the pituitary gonadotropins. Inhibin-like bioactivity has been reported in various fluids and extracts of testis and in ovarian follicular fluid. Although there have been several attempts to purify inhibin from seminal plasma, purification from follicular fluid has been more successful (refs 14-16; for review see ref. 17). We have previously isolated two forms (A and B) of inhibin from porcine follicular fluid. Each form comprised two dissimilar subunits of relative molecular mass (Mr) 18,000 (18K, referred to here as the alpha-subunit) and 14K (the beta-subunit), crosslinked by one or more disulphide bridge(s). Forms A and B differ in the N-terminal sequence of their 14K subunit. Preliminary structural characterization of porcine and bovine ovarian inhibins shows that they have similar properties. Here, we have used the N-terminal amino-acid sequence data on the subunits of each inhibin to identify cloned complementary DNAs encoding the biosynthetic precursors and report that inhibins are the product of a gene family that also includes transforming growth factor-beta (TGF-beta) and whose structural organization is similar to that of pituitary and placental glycoprotein hormones. FAU - Mason, A J AU - Mason AJ FAU - Hayflick, J S AU - Hayflick JS FAU - Ling, N AU - Ling N FAU - Esch, F AU - Esch F FAU - Ueno, N AU - Ueno N FAU - Ying, S Y AU - Ying SY FAU - Guillemin, R AU - Guillemin R FAU - Niall, H AU - Niall H FAU - Seeburg, P H AU - Seeburg PH LA - eng SI - GENBANK/X03265 SI - GENBANK/X03266 SI - GENBANK/X03267 GR - AM18811/AM/NIADDK GR - HD09690/HD/NICHD PT - Journal Article PL - ENGLAND TA - Nature JT - Nature. JID - 0410462 RN - 0 (Macromolecular Substances) RN - 0 (Peptides) RN - 0 (RNA, Messenger) RN - 24937-83-5 (Poly A) RN - 57285-09-3 (Inhibins) RN - 63231-63-0 (RNA) RN - 76057-06-2 (Transforming Growth Factors) RN - 9007-49-2 (DNA) SB - IM MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Cattle MH - DNA/*analysis MH - Female MH - Inhibins/*genetics MH - Macromolecular Substances MH - Molecular Weight MH - Ovarian Follicle/*secretion MH - Peptides/*genetics MH - Poly A/analysis MH - RNA/analysis MH - RNA, Messenger MH - Research Support, Non-U.S. Gov't MH - Research Support, U.S. Gov't, P.H.S. MH - Swine MH - Transforming Growth Factors EDAT- 1985/12/19 MHDA- 1985/12/19 00:01 PST - ppublish SO - Nature. 1985 Dec 19-1986 Jan 1;318(6047):659-63. PMID- 16291338 OWN - NLM STAT- In-Data-Review DA - 20051118 PUBM- Print IS - 0022-3476 (Print) VI - 147 IP - 5 DP - 2005 Nov TI - Making the National Children's Study a Real Partnership with Academic Pediatrics. PG - 563-4 AD - From the Children's Research Center of Michigan, Children's Hospital of Michigan, Detroit. FAU - Lyman, William D AU - Lyman WD FAU - Barone, Charles AU - Barone C FAU - Castle, Valerie AU - Castle V FAU - Guillemin, R AU - Guillemin R FAU - Davies, H Dele AU - Davies HD FAU - Stanton, Bonita AU - Stanton B FAU - Paneth, Nigel AU - Paneth N AU - For The Michigan Alliance For The National Children's Study LA - eng PT - Editorial PL - United States TA - J Pediatr JT - The Journal of pediatrics. JID - 0375410 SB - AIM SB - IM EDAT- 2005/11/18 09:00 MHDA- 2005/11/18 09:00 AID - S0022-3476(05)00843-7 [pii] AID - 10.1016/j.jpeds.2005.08.071 [doi] PST - ppublish SO - J Pediatr. 2005 Nov;147(5):563-4. PMID- 15451956 OWN - NLM STAT- MEDLINE DA - 20041210 DCOM- 20050118 PUBM- Print IS - 0278-2715 (Print) VI - Suppl Web Exclusives DP - 2004 Jan-Jun TI - Recent trends in state nursing home payment policies. PG - W4-363-73 AB - State Medicaid programs pay for a sizable portion of overall nursing home expenditures. The repeal of the Boren amendment in 1997 gave states greater freedom to set Medicaid nursing home policy. This study presents data from a comprehensive survey of state nursing home payment policies during 1999-2002. Aggregate inflation-adjusted Medicaid payment rates rose steadily, and there was no sizable increase in the adoption of other cost-cutting policies. Although these findings can be interpreted with some optimism from a nursing home financing perspective, areas of concern remain for state nursing home policy during the next several years. AD - Department of Health Care Organization and Policy, University of Alabama at Birmingham, USA. grabowsk@uab.edu FAU - Bunn JR, Paul A AU - Bunn P FAU - Grabowski, David C AU - Grabowski DC FAU - Guillemin, R AU - Guillemin R FAU - Feng, Zhanlian AU - Feng Z FAU - Intrator, Orna AU - Intrator O FAU - Mor, Vincent AU - Mor V LA - eng GR - AG11624/AG/NIA GR - AG20557/AG/NIA PT - Journal Article PL - United States TA - Health Aff (Millwood) JT - Health affairs (Project Hope) JID - 8303128 SB - IM MH - Data Collection MH - Medicaid/*economics/*trends MH - Nursing Homes/*economics MH - Reimbursement Mechanisms/*legislation & jurisprudence MH - Research Support, U.S. Gov't, P.H.S. MH - *State Government MH - United States EDAT- 2004/09/29 05:00 MHDA- 2005/01/19 09:00 AID - 10.1377/hlthaff.w4.363 [doi] AID - hlthaff.w4.363 [pii] PST - ppublish SO - Health Aff (Millwood). 2004 Jan-Jun;Suppl Web Exclusives:W4-363-73. PMID- 14653276 OWN - NLM STAT- MEDLINE DA - 20031203 DCOM- 20040413 LR - 20041117 PUBM- Print IS - 1071-9164 (Print) VI - 9 IP - 5 Suppl Nitric Oxide DP - 2003 Oct TI - Nitric oxide's role in heart failure: pathophysiology and treatment. Introduction. PG - S197-8 AD - Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA. FAU - Cohn, Jay N AU - Cohn JN FAU - Loscalzo, Joseph AU - Loscalzo J FAU - Franciosa, Joseph A AU - Franciosa JA FAU - Guillemin, R AU - Guillemin R LA - eng PT - Editorial PL - United States TA - J Card Fail JT - Journal of cardiac failure. JID - 9442138 RN - 0 (Adrenergic beta-Antagonists) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 10102-43-9 (Nitric Oxide) RN - 11128-99-7 (Angiotensin II) SB - IM MH - Adrenergic beta-Antagonists/therapeutic use MH - African Americans MH - Angiotensin II/metabolism MH - Angiotensin-Converting Enzyme Inhibitors/therapeutic use MH - Heart Failure, Congestive/*drug therapy/ethnology/*physiopathology MH - Humans MH - Nitric Oxide/*metabolism MH - Research Support, Non-U.S. Gov't MH - Ventricular Remodeling/drug effects/physiology EDAT- 2003/12/05 05:00 MHDA- 2004/04/14 05:00 PST - ppublish SO - J Card Fail. 2003 Oct;9(5 Suppl Nitric Oxide):S197-8. PMID- 9965612 OWN - NLM STAT- Publisher DA - 19990210 PUBM- Print IS - 1063-651X (Print) VI - 54 IP - 4 DP - 1996 Oct TI - Erratum: Spatial Doppler anomaly in an excitable medium PG - 4483 FAU - Klein, Rachel G AU - Klein RG AU - Wellner M AU - Pertsov AM AU - Jalife J LA - ENG PT - JOURNAL ARTICLE TA - PHYSICAL REVIEW. E. STATISTICAL PHYSICS, PLASMAS, FLUIDS, AND RELATED INTERDISCIPLINARY TOPICS EDAT- 1999/02/19 MHDA- 1999/02/19 PST - ppublish SO - PHYSICAL REVIEW. E. STATISTICAL PHYSICS, PLASMAS, FLUIDS, AND RELATED INTERDISCIPLINARY TOPICS. 1996 Oct;54(4):4483. PMID- 9469584 OWN - NLM STAT- MEDLINE DA - 19980326 DCOM- 19980326 LR - 20051117 PUBM- Print IS - 0022-2275 (Print) VI - 39 IP - 1 DP - 1998 Jan TI - Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol delta7-reductase in liver and mononuclear leukocytes. PG - 44-50 AB - Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol concentrations. Patients have markedly reduced whole body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-controlling enzyme in cholesterol biosynthetic pathway, coupled with significantly increased low density lipoprotein (LDL) receptor expression. To investigate the mechanism of down-regulated cholesterol biosynthesis, we assayed several other key enzymes in the cholesterol biosynthetic pathway including acetoacetyl-CoA thiolase, HMG-CoA synthase, squalene synthase, and 7-dehydrocholesterol delta7-reductase activities in liver and freshly isolated mononuclear leukocytes from four sitosterolemic patients and 19 controls. Hepatic acetoacetyl-CoA thiolase, HMG-CoA synthase, reductase, and squalene synthase activities were significantly decreased (P < 0.05) -39%, -54%, -76%, and -57%, respectively, and 7-dehydrocholesterol delta7-reductase activity tended to be lower (-35%) in the sitosterolemic compared with control subjects. The reduced HMG-CoA synthase, reductase, and squalene synthase activities were also found in mononuclear leukocytes from a sitosterolemic patient. Thus, reduced cholesterol synthesis is caused not only by decreased HMG-CoA reductase but also by the coordinate down-regulation of entire pathway of cholesterol biosynthesis. These results suggest that inadequate cholesterol production in sitosterolemia is due to abnormal down-regulation of early, intermediate, and late enzymes in the cholesterol biosynthetic pathway rather than a single inherited defect in the HMG-CoA reductase gene. AD - Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103, USA. FAU - Klein, Rachel G AU - Klein RG FAU - Honda, A AU - Honda A FAU - Salen, G AU - Salen G FAU - Nguyen, L B AU - Nguyen LB FAU - Tint, G S AU - Tint GS FAU - Batta, A K AU - Batta AK FAU - Shefer, S AU - Shefer S LA - eng GR - HD-31932/HD/NICHD GR - HL-17818/HL/NHLBI PT - Case Reports PT - Journal Article PL - UNITED STATES TA - J Lipid Res JT - Journal of lipid research. JID - 0376606 RN - 0 (Sitosterols) RN - 57-88-5 (Cholesterol) RN - 5779-62-4 (sitosterol) RN - EC 1. (Oxidoreductases) RN - EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases) RN - EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors) RN - EC 1.3.1.21 (7-dehydrocholesterol reductase) RN - EC 2.3.1.9 (Acetyl-CoA C-Acetyltransferase) RN - EC 2.3.3.10 (Hydroxymethylglutaryl-CoA Synthase) RN - EC 2.5.1.21 (Farnesyl-Diphosphate Farnesyltransferase) SB - IM MH - Acetyl-CoA C-Acetyltransferase/deficiency MH - Adult MH - Cholesterol/*biosynthesis MH - Farnesyl-Diphosphate Farnesyltransferase/deficiency MH - Humans MH - Hydroxymethylglutaryl CoA Reductases/deficiency MH - Hydroxymethylglutaryl-CoA Synthase/deficiency MH - Leukocytes, Mononuclear/*enzymology MH - Liver/*enzymology MH - Male MH - Oxidoreductases/deficiency MH - *Oxidoreductases Acting on CH-CH Group Donors MH - Research Support, Non-U.S. Gov't MH - Research Support, U.S. Gov't, Non-P.H.S. MH - Research Support, U.S. Gov't, P.H.S. MH - Sitosterols/*blood EDAT- 1998/02/20 MHDA- 1998/02/20 00:01 PST - ppublish SO - J Lipid Res. 1998 Jan;39(1):44-50. PMID- 8411001 OWN - NLM STAT- MEDLINE DA - 19931109 DCOM- 19931109 LR - 20041117 PUBM- Print IS - 0022-2623 (Print) VI - 36 IP - 20 DP - 1993 Oct 1 TI - Synthesis and relative potencies of new constrained CRF antagonists. PG - 2860-7 AB - Two series of CRF antagonists with N alpha- and C alpha-methylated alanine and leucines were evaluated for their biological activities in vitro and in vivo in several systems. The poly-N-methylated analogue of alpha-helical-CRF9-41, [N alpha MeLeu10,15,27,37,N alpha MeAla22,32,41]-alpha-Hel-CRF9-41, was found to be considerably less potent than the parent non-N-methylated analogue. This result was expected on the basis that alpha-helicity was thought to be required for biological activity and the prediction that backbone substitutions on the nitrogen have a tendency to break alpha-helices (a hypothesis that was confirmed by circular dichroism). Next, a series of constrained analogues of the potent CRF antagonist, [DPhe12,Nle21,38]h/rCRF12-41, was synthesized that contained C alpha-methylleucine and/or C alpha-methylalanine (Aib) residues at selected positions. Because C alpha-methylation is recognized to increase alpha-helicity, and because there is now strong NMR data suggesting that residues 6-36 assume a well-defined alpha-helix, it was expected that these analogues would be more potent. Although usual solid-phase peptide synthesis procedures were followed, success in coupling the C alpha-methyl amino acids was obtained only with a 1:1 mixture of BOP/HOBt. In vitro potencies of the synthesized compounds were measured in a collagenase-dispersed anterior pituitary cell culture bioassay. Monosubstituted analogues were shown to be twice to one fourth as potent as the parent compound; while the pluri-substituted peptides were slightly less potent. This decrease in potency might be correlated to an unexpected lower helical content of the pluri-substituted compounds (as determined by CD spectroscopy), as it was suggested that the bioactive conformation of the CRF was predominantly alpha-helical. Interestingly, one analogue, [DPhe12,Nle21,38,C alpha-MeLeu37]h/rCRF12-41, was found to be more potent and longer acting than the parent compound in two in vivo assays measuring ACTH release after intravenous administration to adrenalectomized rats and reversal of stress-induced delay in gastric emptying in the rat after intracisternal administration. The molecular basis for this increased duration of action and potency is being investigated. AD - Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California 92037. FAU - Hernandez, J F AU - Hernandez JF FAU - Kornreich, W AU - Kornreich W FAU - Rivier, C AU - Rivier C FAU - Miranda, A AU - Miranda A FAU - Yamamoto, G AU - Yamamoto G FAU - Andrews, J AU - Andrews J FAU - Tache, Y AU - Tache Y FAU - Vale, W AU - Vale W FAU - Klein, Rachel G AU - Klein RG FAU - Rivier, J AU - Rivier J LA - eng GR - DK-26741/DK/NIDDK GR - DK-33061/DK/NIDDK GR - MH-00663/MH/NIMH PT - Journal Article PL - UNITED STATES TA - J Med Chem JT - Journal of medicinal chemistry. JID - 9716531 RN - 0 (H-R corticotropin-releasing factor (12-41), Phe(12)-Nle(21,38), C(alpha-MeLeu(37))-) RN - 0 (Peptide Fragments) RN - 0 (phenylalanyl corticotropin-releasing factor (12-41)) RN - 9002-60-2 (Corticotropin) RN - 9015-71-8 (Corticotropin-Releasing Hormone) SB - IM MH - Adrenalectomy MH - Amino Acid Sequence MH - Animals MH - Cells, Cultured MH - Comparative Study MH - Corticotropin/secretion MH - Corticotropin-Releasing Hormone/*analogs & derivatives/*antagonists & inhibitors/chemical synthesis/chemistry/pharmacology MH - Gastric Emptying/drug effects MH - Kinetics MH - Male MH - Molecular Sequence Data MH - Peptide Fragments/*chemical synthesis/pharmacology MH - Pituitary Gland/drug effects/secretion MH - Protein Structure, Secondary MH - Rats MH - Rats, Sprague-Dawley MH - Research Support, U.S. Gov't, P.H.S. MH - Stress/physiopathology MH - Structure-Activity Relationship EDAT- 1993/10/01 MHDA- 1993/10/01 00:01 PST - ppublish SO - J Med Chem. 1993 Oct 1;36(20):2860-7. PMID- 2545230 OWN - NLM STAT- MEDLINE DA - 19890825 DCOM- 19890825 LR - 20051116 PUBM- Print IS - 0893-0341 (Print) VI - 3 IP - 1-2 DP - 1989 Spring-Summer TI - Suggested links between different types of dementias: Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections. PG - 100-9 AB - Several lines of investigation identify common features of Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections. We discuss salient neuropathological, genetic, transmission, and transformation properties that suggest there may be common pathways in the pathogenesis of dementias. We also briefly present potential retroviral mechanisms that may be implicated in all of these dementias. AD - Yale University School of Medicine, Section of Neuropathology, New Haven, CT 06510. FAU - Manuelidis, E E AU - Manuelidis EE FAU - Klein, Rachel G AU - Klein RG FAU - Manuelidis, L AU - Manuelidis L LA - eng GR - AG 03106/AG/NIA GR - NS 12674/NS/NINDS PT - Journal Article PT - Review PL - UNITED STATES TA - Alzheimer Dis Assoc Disord JT - Alzheimer disease and associated disorders. JID - 8704771 SB - IM SB - X MH - Acquired Immunodeficiency Syndrome/*complications MH - Alzheimer Disease/genetics/*microbiology/pathology MH - Animals MH - Brain Diseases/*etiology/pathology MH - Creutzfeldt-Jakob Syndrome/genetics/*microbiology/pathology MH - Humans MH - Research Support, U.S. Gov't, P.H.S. MH - Retroviridae Infections/*pathology RF - 76 EDAT- 1989/01/01 MHDA- 1989/01/01 00:01 PST - ppublish SO - Alzheimer Dis Assoc Disord. 1989 Spring-Summer;3(1-2):100-9. PMID- 4001585 OWN - NLM STAT- MEDLINE DA - 19850724 DCOM- 19850724 LR - 20041117 PUBM- Print IS - 0275-004X (Print) VI - 5 IP - 1 DP - 1985 Winter-Spring TI - Macular hole and retinal detachment in Best's disease. PG - 22-5 AB - The authors report a family with Best's vitelliform macular dystrophy in which one member developed a macular hole and retinal detachment. The retinal detachment was repaired by resultant extensive rhegmatogenous pars plana vitrectomy, fluid-air exchange, and photocoagulation. Examination of the vitreous specimen disclosed numerous large macrophages with abundant cytoplasm distended by lipofuscin. FAU - Schachat, A P AU - Schachat AP FAU - de la Cruz, Z AU - de la Cruz Z FAU - Green, W R AU - Green WR FAU - Patz, A AU - Patz A FAU - Klein, Rachel G AU - Klein RG LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Retina JT - Retina (Philadelphia, Pa.) JID - 8309919 SB - IM MH - Adolescent MH - Adult MH - Child MH - Humans MH - Light Coagulation MH - Macula Lutea/pathology MH - Macular Degeneration/*complications/genetics/pathology MH - Male MH - Retinal Detachment/*etiology/surgery/therapy MH - Retinal Perforations/*etiology MH - Vitrectomy EDAT- 1985/01/01 MHDA- 1985/01/01 00:01 PST - ppublish SO - Retina. 1985 Winter-Spring;5(1):22-5. PMID- 6148773 OWN - NLM STAT- MEDLINE DA - 19841113 DCOM- 19841113 LR - 20041117 PUBM- Print IS - 0079-9963 (Print) VI - 40 DP - 1984 TI - Somatocrinin, the growth hormone releasing factor. PG - 233-99 FAU - Guillemin, R AU - Guillemin R FAU - Brazeau, P AU - Brazeau P FAU - Bohlen, P AU - Bohlen P FAU - Esch, F AU - Esch F FAU - Ling, N AU - Ling N FAU - Wehrenberg, W B AU - Wehrenberg WB FAU - Bloch, B AU - Bloch B FAU - Mougin, C AU - Mougin C FAU - Zeytin, F AU - Zeytin F FAU - Baird, A AU - Baird A LA - eng GR - AM-18811/AM/NIADDK GR - HD-09690/HD/NICHD PT - Journal Article PT - Review PL - UNITED STATES TA - Recent Prog Horm Res JT - Recent progress in hormone research. JID - 0404471 RN - 0 (Amino Acids) RN - 0 (Peptide Fragments) RN - 0 (Prostaglandins E) RN - 0 (Protein Precursors) RN - 363-24-6 (Dinoprostone) RN - 51110-01-1 (Somatostatin) RN - 60-92-4 (Cyclic AMP) RN - 9002-72-6 (Growth Hormone) RN - 9034-39-3 (Somatotropin-Releasing Hormone) RN - EC 4.6.1.1 (Adenylate Cyclase) SB - IM MH - Adenylate Cyclase/physiology MH - Amino Acid Sequence MH - Amino Acids/analysis MH - Animals MH - Brain/drug effects MH - Cells, Cultured MH - Chemistry MH - Chromatography MH - Chromatography, High Pressure Liquid MH - Comparative Study MH - Cyclic AMP/physiology MH - Dinoprostone MH - Dose-Response Relationship, Drug MH - Growth Hormone/secretion MH - Histocytochemistry MH - Humans MH - Hypothalamus/analysis MH - Pancreatic Neoplasms/analysis MH - Peptide Fragments/antagonists & inhibitors/chemical synthesis/diagnostic use/isolation & purification/pharmacology/*physiology MH - Pituitary Gland/drug effects/secretion MH - Prostaglandins E/pharmacology MH - Protein Precursors MH - Radioimmunoassay MH - Research Support, Non-U.S. Gov't MH - Research Support, U.S. Gov't, P.H.S. MH - Somatostatin/pharmacology MH - Somatotropin-Releasing Hormone/antagonists & inhibitors/chemical synthesis/diagnostic use/isolation & purification/pharmacology/*physiology MH - Structure-Activity Relationship MH - Tissue Distribution RF - 99 EDAT- 1984/01/01 MHDA- 1984/01/01 00:01 PST - ppublish SO - Recent Prog Horm Res. 1984;40:233-99. PMID- 4455659 OWN - NLM STAT- MEDLINE DA - 19750620 DCOM- 19750620 LR - 20041117 PUBM- Print IS - 0020-7640 (Print) VI - 20 IP - 3-4 DP - 1974 Autumn-Winter TI - Some folk beliefs about mental illness: a reconsideration. PG - 292-6 FAU - Karno, M AU - Karno M FAU - Klein, Rachel G AU - Klein RG LA - eng PT - Journal Article PL - ENGLAND TA - Int J Soc Psychiatry JT - The International journal of social psychiatry. JID - 0374726 SB - IM MH - Acculturation MH - *Attitude to Health MH - California MH - England/ethnology MH - *Ethnic Groups MH - *Folklore MH - Humans MH - *Mental Disorders/genetics MH - Mexico/ethnology MH - Rural Population EDAT- 1974/01/01 MHDA- 1974/01/01 00:01 PST - ppublish SO - Int J Soc Psychiatry. 1974 Autumn-Winter;20(3-4):292-6. PMID- 4902833 OWN - NLM STAT- MEDLINE DA - 19700205 DCOM- 19700205 LR - 20041117 PUBM- Print IS - 0028-4793 (Print) VI - 282 IP - 4 DP - 1970 Jan 22 TI - Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. PG - 198-206 FAU - Waldvogel, F A AU - Waldvogel FA FAU - Klein, Rachel G AU - Klein RG FAU - Medoff, G AU - Medoff G FAU - Swartz, M N AU - Swartz MN LA - eng PT - Journal Article PT - Review PL - UNITED STATES TA - N Engl J Med JT - The New England journal of medicine. JID - 0255562 RN - 0 (Anti-Bacterial Agents) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Aged MH - Anti-Bacterial Agents/therapeutic use MH - Bone and Bones/pathology MH - Child MH - Child, Preschool MH - Chronic Disease MH - Female MH - Focal Infection/complications MH - Humans MH - Infant MH - Male MH - Middle Aged MH - *Osteomyelitis/classification/diagnosis/drug therapy/epidemiology/etiology/microbiology/pathology/physiopathology/radio graphy MH - Prognosis RF - 71 EDAT- 1970/01/22 MHDA- 1970/01/22 00:01 PST - ppublish SO - N Engl J Med. 1970 Jan 22;282(4):198-206. PMID- 14560782 OWN - NLM STAT- MEDLINE DA - 20031016 DCOM- 20031204 LR - 20041117 PUBM- Print IS - 0889-8588 (Print) VI - 17 IP - 5 DP - 2003 Oct TI - Polycythemia vera. PG - 1191-210 AB - The differential diagnosis of an elevated hematocrit and the criteria for the diagnosis of polycythemia vera present little or no problem; however, there is not a consensus on therapy. Spivak likened this to a conundrum--"an intricate and difficult problem." Nonetheless, it can be argued that on the basis of the following criteria--life expectancy, the absence of toxicity, and long remissions an average of 3.1 years or a median of 2 years--and with acute leukemia no more common than in other regimens except phlebotomy alone (a regimen that cannot be sustained), 32P should be the treatment of choice except in pregnant women. Others, but not all, share this view. This is in contrast to the statement, "Thus chemotherapy treatment of [polycythemia vera] patients is not as easy, innocuous, and well tolerated as it is generally believed". Patients treated with phlebotomy alone were subjected to an unacceptably high incidence of early thrombotic events. Unavailability of pipobroman eliminates this choice. AD - Department of Medicine, Northwestern University, Chicago, IL, USA. nberlin@pol.net LA - eng PT - Journal Article PT - Review PL - United States TA - Hematol Oncol Clin North Am JT - Hematology/oncology clinics of North America. JID - 8709473 RN - 0 (Antineoplastic Agents) RN - 127-07-1 (Hydroxyurea) RN - 9008-11-1 (Interferons) SB - IM EIN - Hematol Oncol Clin North Am. 2004 Feb;18(1):xv. Berlin Nathanial I [corrected to Berlin Nathaniel] MH - Antineoplastic Agents/therapeutic use MH - Diagnosis, Differential MH - Hematocrit MH - Humans MH - Hydroxyurea/therapeutic use MH - Interferons/therapeutic use MH - Phlebotomy MH - Polycythemia Vera/blood/diagnosis/*physiopathology/therapy RF - 112 EDAT- 2003/10/17 05:00 MHDA- 2003/12/05 05:00 PST - ppublish SO - Hematol Oncol Clin North Am. 2003 Oct;17(5):1191-210.