PMID- 12517080 OWN - NLM STAT- MEDLINE DA - 20030108 DCOM- 20030210 LR - 20050419 PUBM- Print IS - 0031-7179 (Print) VI - 64 IP - 2 DP - 2001 Spring TI - Commentary: Humanity and personhood. PG - 11 AD - Vanderbilt University School of Medicine, Nashville, Tennessee 37215-1812, USA. FAU - van Eys, J AU - van Eys J LA - eng PT - Comment PT - Journal Article PL - United States TA - Pharos Alpha Omega Alpha Honor Med Soc JT - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. JID - 19610620R SB - E SB - IM CON - Pharos Alpha Omega Alpha Honor Med Soc. 2001 Spring;64(2):4-9. PMID: 12517078 MH - Brain Injury, Chronic/*therapy MH - Decision Making/*ethics MH - Humans MH - Hypoxia-Ischemia, Brain/*therapy MH - Infant, Newborn MH - Life Support Care/*ethics MH - *Personhood OID - KIE: 119235 OTO - KIE OT - Death and Euthanasia GN - KIE: 3 refs. GN - KIE: KIE Bib: allowing to die/infants; personhood EDAT- 2003/01/09 04:00 MHDA- 2003/02/11 04:00 PST - ppublish SO - Pharos Alpha Omega Alpha Honor Med Soc 2001 Spring;64(2):11. PMID- 11649563 OWN - KIE STAT- MEDLINE DA - 19850518 DCOM- 19850518 LR - 20041118 PUBM- Print IS - 0193-7758 (Print) VI - 6 IP - 4 DP - 1984 Jul-Aug TI - The concept of the IRB and bureaucratic reality: an exchange of letters. PG - 8-10 FAU - van Eys, Jan AU - van Eys J FAU - Levine, Robert J AU - Levine RJ LA - eng PT - Journal Article PT - Letter PL - United States TA - IRB JT - IRB JID - 7906878 RN - 0 (Pharmaceutical Preparations) SB - E MH - Conflict of Interest MH - *Consent Forms MH - *Drug Industry MH - *Ethical Review MH - *Ethics MH - *Ethics Committees MH - *Ethics Committees, Research MH - *Evaluation Studies MH - *Federal Government MH - Financial Support MH - *Government MH - *Government Regulation MH - *Human Experimentation MH - Humans MH - *Informed Consent MH - National Institutes of Health (U.S.) MH - *Neoplasms MH - Patient Selection MH - Pharmaceutical Preparations MH - *Public Policy MH - Random Allocation MH - *Research Design MH - Research Subjects MH - *Social Control, Formal MH - *Social Control, Informal MH - United States Food and Drug Administration OID - KIE: 18449 OTO - KIE OT - Biomedical and Behavioral Research OT - DHHS Guidelines OT - Legal Approach OT - National Cancer Institute OT - National Institutes of Health GN - KIE: KIE BoB Subject Heading: human experimentation/ethics committees GN - KIE: KIE BoB Subject Heading: human experimentation/informed consent GN - KIE: KIE BoB Subject Heading: human experimentation/regulation GN - KIE: Article and commentary EDAT- 2001/10/20 10:00 MHDA- 2001/11/02 10:01 PST - ppublish SO - IRB 1984 Jul-Aug;6(4):8-10. PMID- 10992916 OWN - NLM STAT- MEDLINE DA - 20001006 DCOM- 20001006 LR - 20041117 PUBM- Print IS - 0031-7179 (Print) VI - 62 IP - 4 DP - 1999 Fall TI - The concept of cure and the quality of life. PG - 24-5 FAU - van Eys, J AU - van Eys J LA - eng PT - Journal Article PL - UNITED STATES TA - Pharos Alpha Omega Alpha Honor Med Soc JT - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. JID - 19610620R SB - IM MH - *Adaptation, Psychological MH - Age of Onset MH - Brain Neoplasms/*psychology/*therapy MH - Child MH - Humans MH - *Quality of Life EDAT- 2000/09/19 11:00 MHDA- 2000/10/14 11:01 PST - ppublish SO - Pharos Alpha Omega Alpha Honor Med Soc 1999 Fall;62(4):24-5. PMID- 9876482 OWN - NLM STAT- MEDLINE DA - 19990114 DCOM- 19990114 LR - 20041117 PUBM- Print IS - 0898-6924 (Print) VI - 11 DP - 1998 TI - Benefits of nutritional intervention on nutritional status, quality of life and survival. PG - 66-8 AB - Most cancers in children are acute diseases. Therefore, the incidence of malnutrition, in general, is not different from the incidence in the referral population. Some specific tumors, such as neuroblastoma and those resulting in the diencephalic syndrome, can be exceptions. By contrast, malnutrition is a frequent problem during modern intensive cancer treatment as the result of the associated anorexia, altered taste sensations and catabolic effects of drugs. In addition, there are psychogenic factors and metabolic consequences associated with the tumor itself. Nutritional support does improve the feeling of well-being and performance status, while maintaining or improving the immune competence, thereby potentially affecting survival by limiting infectious episodes. There is no convincing evidence to date that nutritional support has an antineoplastic effect per se, but deficiency of a specific nutrient might be beneficial because of a differential requirement between tumor and normal cells. Theoretically, nutritional support might enhance tumor growth but also susceptibility to chemotherapy. In either case, nutrition is a support modality that must be given with appropriate tumor-directed therapy if curative intent is the goal of treatment. Nutrition remains a consideration after therapy is completed. This generates different challenges. If further tumor-directed therapy is futile, the decision to continue nutritional support is difficult, but if the child is well, nutritional rehabilitation must be pursued. Finally, the cured child continues to benefit from dietary advice. Nutrition should be viewed for what it is: supplying the most basic need of children. AD - Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA. FAU - Van Eys, J AU - Van Eys J LA - eng PT - Journal Article PL - UNITED STATES TA - Int J Cancer Suppl JT - International journal of cancer. Supplement = Journal international du cancer. Supplement. JID - 8710267 SB - IM MH - Child MH - Humans MH - Neoplasms/*complications/mortality/therapy MH - Nutrition Disorders/*complications/*therapy MH - Quality of Life MH - Recurrence MH - Remission Induction MH - Survival Rate EDAT- 1999/01/07 MHDA- 1999/01/07 00:01 PST - ppublish SO - Int J Cancer Suppl 1998;11:66-8. PMID- 9564244 OWN - NLM STAT- MEDLINE DA - 19980604 DCOM- 19980604 LR - 20041117 PUBM- Print IS - 1088-6222 (Print) VI - 91 IP - 4 DP - 1998 Apr TI - Ethics and managed care. PG - 127 AD - Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, USA. FAU - van Eys, J AU - van Eys J LA - eng PT - Journal Article PL - UNITED STATES TA - Tenn Med JT - Tennessee medicine : journal of the Tennessee Medical Association. JID - 9609310 SB - IM CIN - Tenn Med. 1998 Apr;91(4):125-6. PMID: 9564243 MH - *Ethics, Medical MH - Humans MH - Managed Care Programs/*economics MH - United States EDAT- 1998/05/02 MHDA- 1998/05/02 00:01 PST - ppublish SO - Tenn Med 1998 Apr;91(4):127. PMID- 9049886 OWN - NLM STAT- MEDLINE DA - 19970508 DCOM- 19970508 LR - 20041117 PUBM- Print IS - 0167-594X (Print) VI - 32 IP - 3 DP - 1997 May TI - MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. PG - 243-52 AB - Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity. A trial of mechlorethamine, vincristine (oncovin), procarbazine, and prednisone (MOPP) was performed to test the hypothesis that replacing radiotherapy with chemotherapy would improve survival and decrease long term morbidity of infants who have brain tumors. Between 1976 and 1988, 17 consecutive children less than 36 months old when diagnosed with medulloblastoma or ependymoma were treated with MOPP chemotherapy as primary therapy following surgical excision or biopsy of the tumor. Radiotherapy was reserved for recurrent disease. Ten of 17 children have survived without evidence of disease: medulloblastoma eight of 12 with median survival time of 10.6 years (range, 6.2 to 15.2 yrs); and ependymoma, 2 of 5 (at 13.0 and 16.0 yrs). Four of the 10 children with medulloblastoma and ependymoma who relapsed are now disease free at 7.5, 11.7, 12.2 and 13.5 yrs post relapse after receiving salvage therapy with cisplatin (n = 1) or irradiation (n = 3). All relapses occurred within 26 months of diagnosis. Data on growth demonstrated height less than the 5th percentile in all children who received cranial irradiation compared to 25 to 95th percentile for nonirradiated children. Intellectual ability for the group who did not require radiation was within normal range (mean IQ 100.1) and stable across annual assessments. Those who required radiation had lower IOs which continued to decline over time (mean IQ 85 at mean age of 5.8 years, declining to 63 at 10 years). In young children with brain tumors, primary chemotherapy with MOPP, omitting radiotherapy, provides improved neurodevelopmental outcome and survival. AD - Department of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, USA. FAU - Ater, J L AU - Ater JL FAU - van Eys, J AU - van Eys J FAU - Woo, S Y AU - Woo SY FAU - Moore, B 3rd AU - Moore B 3rd FAU - Copeland, D R AU - Copeland DR FAU - Bruner, J AU - Bruner J LA - eng GR - RO1-CA33097/CA/NCI PT - Journal Article PL - NETHERLANDS TA - J Neurooncol JT - Journal of neuro-oncology. JID - 8309335 RN - 0 (Antineoplastic Combined Chemotherapy Protocols) RN - 0 (MOPP protocol) RN - 51-75-2 (Mechlorethamine) RN - 53-03-2 (Prednisone) RN - 57-22-7 (Vincristine) RN - 671-16-9 (Procarbazine) SB - IM MH - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use MH - Brain Neoplasms/*drug therapy/mortality/psychology/surgery MH - Cerebellar Neoplasms/*drug therapy/mortality/psychology/surgery MH - Chemotherapy, Adjuvant MH - Ependymoma/*drug therapy/mortality/psychology/surgery MH - Female MH - Follow-Up Studies MH - Humans MH - Infant MH - Intelligence Tests MH - Male MH - Mechlorethamine/administration & dosage/adverse effects MH - Medulloblastoma/*drug therapy/mortality/psychology/surgery MH - Prednisone/administration & dosage/adverse effects MH - Procarbazine/administration & dosage/adverse effects MH - Research Support, U.S. Gov't, P.H.S. MH - Treatment Outcome MH - Vincristine/administration & dosage/adverse effects EDAT- 1997/05/01 MHDA- 2001/03/28 10:01 PST - ppublish SO - J Neurooncol 1997 May;32(3):243-52. PMID- 9074318 OWN - NLM STAT- MEDLINE DA - 19970411 DCOM- 19970411 LR - 20041117 PUBM- Print IS - 0031-7179 (Print) VI - 59 IP - 3 DP - 1996 Summer TI - Ethics and mathematics: from Teiresias to Fletcher. PG - 21-5 FAU - van Eys, J AU - van Eys J LA - eng PT - Biography PT - Historical Article PT - Journal Article PL - UNITED STATES TA - Pharos Alpha Omega Alpha Honor Med Soc JT - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. JID - 19610620R SB - IM SB - Q MH - Ethics, Medical/*history MH - History, 20th Century MH - History, Ancient MH - Mathematics/history MH - Morals MH - Social Justice MH - Social Values PS - Fletcher J FPS - Fletcher, J EDAT- 1996/01/01 MHDA- 1996/01/01 00:01 PST - ppublish SO - Pharos Alpha Omega Alpha Honor Med Soc 1996 Summer;59(3):21-5. PMID- 8403744 OWN - NLM STAT- MEDLINE DA - 19931022 DCOM- 19931022 LR - 20041117 PUBM- Print IS - 0009-9228 (Print) VI - 32 IP - 8 DP - 1993 Aug TI - Early hospital discharge and the timing of newborn metabolic screening. PG - 463-6 AB - Cost containment measures have reduced dramatically the length of stay for normal newborns, in some cases jeopardizing the ability to obtain appropriate newborn screens. In our hospital, we found that an unacceptable number of patients had mistakenly been screened before 24 hours of age. As pressures to shorten hospitalization increase, health-care providers must examine the impact of such changes on their ability to obtain adequate newborn screens. Potential solutions include continued vigilance in gathering specimens after 24 hours of age, interpretation of time-sensitive tests in an age-adjusted manner, and repeating newborn screens after 24 hours of age. AD - University of Texas Medical School at Houston 77030. FAU - Coody, D AU - Coody D FAU - Yetman, R J AU - Yetman RJ FAU - Montgomery, D AU - Montgomery D FAU - van Eys, J AU - van Eys J LA - eng PT - Consensus Development Conference, NIH PL - UNITED STATES TA - Clin Pediatr (Phila) JT - Clinical pediatrics. JID - 0372606 SB - AIM SB - IM MH - Cesarean Section MH - Delivery, Obstetric MH - Health Maintenance Organizations MH - Hospitals, Private MH - Hospitals, Teaching MH - Humans MH - *Infant, Newborn MH - *Insurance, Health MH - Medicaid MH - *Neonatal Screening MH - *Nurseries, Hospital MH - *Patient Discharge MH - Social Security MH - Time Factors MH - United States EDAT- 1993/08/01 MHDA- 1993/08/01 00:01 PST - ppublish SO - Clin Pediatr (Phila) 1993 Aug;32(8):463-6.